Tobias T J
Brain Res. 1975 Jan 10;83(2):191-212. doi: 10.1016/0006-8993(75)90930-0.
Thalamic afferents to Macaque prefrontal cortex from the mediodorsal nucleus were examined by techniques specific for anterograde degeneration and axoplasmic transport. The sampling procedure employed permits establishing the extent of topographic projections to cortex from subcortical foci for the same brain which was surveyed subsequently in tracing specific neuronal connections by electron microscopy. Topographic and general laminar distribution of thalamic terminals are presented in terms of 3 subareas of prefrontal cortex. The dorsolateral and ventral (orbital) surfaces of prefrontal cortex receive respectively projections from the lateral and medial subdivision of the mediodorsal nucleus. In addition, the medial wall of the frontal lobe, including the dorsomedial part of the lateral convexity, heretofore regarded as athalamic, receives input from the caudal-dorsomedial aspect of the mediodorsal nucleus. Preliminary evidence suggests that axons from the mediodorsal nucleus terminate in the head of caudate nucleus, as Sachs-81 described 65 years ago in the first orthograde study of thalamo-prefrontal cortex connections.
运用顺行性变性和轴浆运输的特异性技术，对猕猴前额叶皮质来自内侧背核的丘脑传入纤维进行了研究。所采用的取样程序能够确定同一大脑中从皮质下灶投射到皮质的地形学范围，随后通过电子显微镜追踪特定神经元连接时对该大脑进行了检测。丘脑终末的地形学和一般层状分布是根据前额叶皮质的3个亚区呈现的。前额叶皮质的背外侧和腹侧（眶部）表面分别接受来自内侧背核外侧和内侧亚区的投射。此外，额叶的内侧壁，包括外侧凸面的背内侧部分，此前被认为是无丘脑投射的，现发现接受来自内侧背核尾侧-背内侧部分的输入。初步证据表明，内侧背核的轴突终止于尾状核头部，正如65年前萨克斯-81在丘脑-前额叶皮质连接的首次顺行性研究中所描述的那样。
