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本文引用的文献

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Propagation in a fluid medium of a human epidermoid carcinoma, strain KB.人表皮样癌KB株在流体介质中的增殖
Proc Soc Exp Biol Med. 1955 Jul;89(3):362-4. doi: 10.3181/00379727-89-21811.
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Therapeutic effect of 1 M tegafur-0.4 M 5-chloro-2, 4-dihydroxypridine-1 M potassium oxonate (S-1) on head and neck squamous carcinoma cells.
Cancer Lett. 2000 Oct 16;159(1):1-7. doi: 10.1016/s0304-3835(00)00495-x.
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An antioxidant, probucol, induces anti-angiogenesis and apoptosis in athymic nude mouse xenografted human head and neck squamous carcinoma cells.抗氧化剂普罗布考可诱导无胸腺裸鼠异种移植的人头颈鳞状癌细胞发生抗血管生成和凋亡。
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A selective cyclooxygenase-2 inhibitor suppresses tumor growth in nude mouse xenografted with human head and neck squamous carcinoma cells.一种选择性环氧化酶-2抑制剂可抑制接种人头颈鳞状癌细胞的裸鼠体内肿瘤生长。
Jpn J Cancer Res. 1999 Oct;90(10):1152-62. doi: 10.1111/j.1349-7006.1999.tb00690.x.
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Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators.一种新型口服5-氟尿嘧啶衍生物（S-1）的研发，该衍生物通过两种生化调节剂增强5-氟尿嘧啶的肿瘤选择性细胞毒性。
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Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats.氧嗪酸对大鼠5-氟尿嘧啶胃肠道毒性的抑制作用，且不丧失其抗肿瘤活性。
Cancer Res. 1993 Sep 1;53(17):4004-9.
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Inhibition by probucol of interleukin 1 secretion and its implication in atherosclerosis.普罗布考对白细胞介素1分泌的抑制作用及其在动脉粥样硬化中的意义。
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Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.
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Native and oxidized LDL enhances production of PDGF AA and the surface expression of PDGF receptors in cultured human smooth muscle cells.天然和氧化型低密度脂蛋白可增强培养的人平滑肌细胞中血小板衍生生长因子AA的产生及血小板衍生生长因子受体的表面表达。
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晚期头颈癌肿瘤休眠疗法的实验模型

An experimental model of tumor dormancy therapy for advanced head and neck carcinoma.

作者信息

Nishimura G, Yanoma S, Satake K, Ikeda Y, Taguchi T, Nakamura Y, Hirose F, Tsukuda M

机构信息

Department of Otorhinolaryngology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama 236-0004, Japan.

出版信息

Jpn J Cancer Res. 2000 Nov;91(11):1199-203. doi: 10.1111/j.1349-7006.2000.tb00905.x.

DOI:10.1111/j.1349-7006.2000.tb00905.x
PMID:11092987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5926286/
Abstract

An experimental model of tumor dormancy therapy for advanced head and neck carcinoma was developed. After transplantation of KB cells into nude mice, the mice were given tiracoxib, a selective cyclooxygenase (COX)-2 inhibitor, probucol, an antioxidant, and S-1, an oral pro-drug of 5-fluorouracil (5-FU), or combinations of two of them. The combined administration of tiracoxib with probucol significantly inhibited the tumor growth. The angiogenesis in this group was markedly reduced. Tiracoxib and probucol did not affect the intratumoral concentration of 5-FU when coadministered with S-1. The combined use of tiracoxib and probucol is thus a candidate for use in maintenance therapy after the primary therapy for patients with advanced head and neck carcinoma.

摘要

建立了晚期头颈癌肿瘤休眠治疗的实验模型。将KB细胞移植到裸鼠体内后，给小鼠服用塞来昔布（一种选择性环氧化酶（COX）-2抑制剂）、普罗布考（一种抗氧化剂）和S-1（5-氟尿嘧啶（5-FU）的口服前体药物），或其中两种药物的组合。塞来昔布与普罗布考联合给药显著抑制了肿瘤生长。该组的血管生成明显减少。塞来昔布和普罗布考与S-1合用时不影响肿瘤内5-FU的浓度。因此，塞来昔布和普罗布考联合使用是晚期头颈癌患者初始治疗后维持治疗的候选方案。