Trzcińska A, Litwińska B, Kańtoch M
Department of Virology, National Institute of Hygiene, Warsaw, Poland.
Acta Microbiol Pol. 2000;49(2):101-11.
Immunogenic activity of herpes simplex type 1 temperature sensitive mutant's (ts HSV-1 mutant) proteins was tested in two systems: monovalent and polyvalent with other attenuated virus strains (measles and mumps). The guinea pigs were used as animal model. In monovalent system the humoral response in animals infected with ts HSV-1 mutant (1 or 2 doses) was studied and compared to results received for HSV-1 native strain. In polyvalent system the immunological response induced by ts HSV-1 mutant in the presence of RNA virus strains was tested.
在两个系统中测试了单纯疱疹病毒1型温度敏感突变株（ts HSV-1突变株）蛋白的免疫原活性：与其他减毒病毒株（麻疹病毒和腮腺炎病毒）组成的单价和多价系统。以豚鼠作为动物模型。在单价系统中，研究了感染ts HSV-1突变株（1剂或2剂）的动物的体液反应，并与感染单纯疱疹病毒1型野生株所获得的结果进行比较。在多价系统中，测试了在RNA病毒株存在的情况下ts HSV-1突变株诱导的免疫反应。
