核型为47,XXX的女性向男性变性者。
Female-to-male transsexual with 47,XXX karyotype.
作者信息
Turan M T, Eşel E, Dündar M, Candemir Z, Baştürk M, Sofuoğlu S, Ozkul Y
机构信息
Department of Psychiatry, Erciyes University School of Medicine, Kayseri, Turkey.
出版信息
Biol Psychiatry. 2000 Dec 1;48(11):1116-7. doi: 10.1016/s0006-3223(00)00954-9.
BACKGROUND
There are few reports describing chromosomal abnormalities in transsexuals. In rare cases, transsexualism and sexual chromosomal multiplicity coexist. Six cases of male-to-female transsexuals with 47,XYY chromosomal pattern have been previously reported. We have not encountered any female transsexual cases with 47,XXX karyotype in the literature.
METHODS
A 21-year-old female patient came to our outpatient department with depressive symptoms and suicidal thoughts. On psychiatric interview, she reported that she had feelings of discomfort with her gender identity and had desired to be male since her childhood. Then, we performed cytogenetic investigation using blood culture and G chromosome banding.
RESULTS
Histology and DNA histograms of the patient revealed a chromosomal pattern of 47,XXX.
CONCLUSIONS
We conclude that sexual chromosomal abnormalities in some transsexuals may cause a vulnerability to development of a gender identity disorder.
背景
关于变性者染色体异常的报道较少。在罕见情况下，变性症与性染色体多倍体共存。此前已有6例具有47,XYY染色体模式的男性变女性变性者的报道。在文献中我们尚未遇到任何具有47,XXX核型的女性变性者病例。
方法
一名21岁女性患者因抑郁症状和自杀念头前来我院门诊。在精神科访谈中，她报告称自己对自己的性别认同感到不适，自童年起就渴望成为男性。然后，我们使用血培养和G染色体显带技术进行了细胞遗传学调查。
结果
患者的组织学和DNA直方图显示为47,XXX的染色体模式。
结论
我们得出结论，一些变性者的性染色体异常可能导致易患性别认同障碍。
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