Altman A, Isakov N, Baier G
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.
Immunol Today. 2000 Nov;21(11):567-73. doi: 10.1016/s0167-5699(00)01749-7.
Recent studies have identified protein kinase Cθ (PKCtheta), a member of the Ca(2+)-independent PKC family, as an essential component of the T-cell synapse that cooperates with calcineurin to activate the interleukin-2 (IL-2) gene. Several selective functions of PKCtheta involved in the activation and survival of T cells are reviewed herein. Among these, the nuclear factor-kappaB (NF-kappaB) signaling cascade appears to be the most critical target of PKCtheta in the T-cell receptor/CD28 costimulatory pathway that leads to T-cell activation.
最近的研究已确定蛋白激酶Cθ（PKCθ），即不依赖钙的PKC家族的一员，是T细胞突触的一个重要组成部分，它与钙调神经磷酸酶协同作用以激活白细胞介素-2（IL-2）基因。本文综述了PKCθ参与T细胞活化和存活的几种选择性功能。其中，核因子κB（NF-κB）信号级联似乎是PKCθ在导致T细胞活化的T细胞受体/CD28共刺激途径中最关键的靶点。
