Weyand C M, Goronzy J J, Takemura S, Kurtin P J
Division of Rheumatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Arthritis Res. 2000;2(6):457-63. doi: 10.1186/ar128. Epub 2000 Aug 31.
In rheumatoid arthritis, T cells and B cells participate in the immune responses evolving in the synovial lesions. Interaction between T cells and B cells is probably antigen specific because complex microstructures typical of secondary lymphoid organs are generated. Differences between patients in forming follicles with germinal centers, T-cell-B-cell aggregates without germinal center reactions, or loosely organized T-cell-B-cell infiltrates might reflect the presence of different antigens or a heterogeneity in host response patterns to immune injury. Tertiary lymphoid microstructures in the rheumatoid lesions can enhance the sensitivity of antigen recognition, optimize the collaboration of immunoregulatory and effector cells, and support the interaction between the tissue site and the aberrant immune response. The molecular basis of lymphoid organogenesis studied in gene-targeted mice will provide clues to why the synovium is a preferred site for tertiary lymphoid tissue. B cells have a critical role in lymphoid organogenesis. Their contribution to synovial inflammation extends beyond antibody secretion and includes the activation and regulation of effector T cells.
在类风湿性关节炎中，T细胞和B细胞参与滑膜病变中发生的免疫反应。T细胞和B细胞之间的相互作用可能是抗原特异性的，因为会产生典型的二级淋巴器官复杂微观结构。患者在形成带有生发中心的滤泡、没有生发中心反应的T细胞 - B细胞聚集体或松散组织的T细胞 - B细胞浸润方面存在差异，这可能反映了不同抗原的存在或宿主对免疫损伤反应模式的异质性。类风湿病变中的三级淋巴微观结构可增强抗原识别的敏感性，优化免疫调节细胞和效应细胞的协作，并支持组织部位与异常免疫反应之间的相互作用。在基因靶向小鼠中研究的淋巴器官发生的分子基础将为滑膜为何是三级淋巴组织的优先部位提供线索。B细胞在淋巴器官发生中起关键作用。它们对滑膜炎症的作用不仅限于抗体分泌，还包括效应T细胞的激活和调节。
