Hathaway D K, Wicks M N, Cashion A K, Cowan P A, Milstead E J, Gaber A O
College of Nursing, University of Tennessee, Memphis, USA.
West J Nurs Res. 2000 Oct;22(6):749-68. doi: 10.1177/01939450022044728.
A prospective evaluation of 37 kidney and 20 kidney-pancreas transplant recipients was conducted to assess the relationship between pre- to posttransplant changes in heart rate variability (HRV) and quality of life (QoL). Assessments of 24-hour interbeat variability (pNN50 and rMSSD, SDNN, SDANN) and power spectral analysis of total, low (sympathetic), and high (parasympathetic) frequency components of HRV were performed. The Sickness Impact Profile was used to assess three dimensions of QoL (physical, psychosocial, and total functioning) prior to and at 6 months following transplantation. Changes in vagally mediated time domain measures of HRV were related to changes in physical and total functioning. Stronger correlations occurred between biobehavioral measures in kidney-pancreas recipients, with the strongest relationships occurring between changes in HRV frequency domain measures and changes in physical functioning. Findings indicate that changes in HRV and QoL are related, suggesting that interventions that enhance transplant recipients' HRV may also enhance their QoL.
对37名肾移植受者和20名肾胰联合移植受者进行了一项前瞻性评估，以评估移植前后心率变异性（HRV）变化与生活质量（QoL）之间的关系。对24小时心跳间期变异性（pNN50、rMSSD、SDNN、SDANN）以及HRV的总频率、低频（交感神经）和高频（副交感神经）成分进行了功率谱分析。使用疾病影响量表在移植前和移植后6个月评估生活质量的三个维度（身体、心理社会和整体功能）。HRV的迷走神经介导时域测量变化与身体和整体功能变化相关。肾胰联合移植受者的生物行为测量之间存在更强的相关性，HRV频域测量变化与身体功能变化之间的关系最为密切。研究结果表明，HRV和QoL的变化相关，这表明增强移植受者HRV的干预措施也可能提高他们的生活质量。
