Timofeeva N M, Iezuitova N N, Gromova L V
I. P. Pavlov Institute of Physiology, RAS, St. Petersburg.
Usp Fiziol Nauk. 2000 Oct-Dec;31(4):24-37.
The review is mainly devoted to the development of ideas about absorption, or transport, of basic nutrients in the small intestine in humans and higher animal. The absorption processes have been characterized on the example of such substances, vital for organism, as carbohydrates and proteins. The review considers a molecular structure of transporters--protein molecules, which take part in a transfer of the products of lumenal and membrane digestion of carbohydrates (glucose, galactose, fructose) and proteins (amino acids, oligopeptides) across the enterocyte membranes. An information is presented about genetic disturbances of transport of certain amino acids during such diseases as Hartnup disease, cystinuria, and iminoglycineuria.
这篇综述主要致力于阐述人类和高等动物小肠中基本营养物质吸收或转运的相关理念发展。吸收过程已通过对碳水化合物和蛋白质等对生物体至关重要的物质进行举例说明。该综述探讨了转运蛋白的分子结构,这些蛋白质分子参与碳水化合物(葡萄糖、半乳糖、果糖)和蛋白质(氨基酸、寡肽)在肠腔和膜消化产物跨肠细胞膜的转运过程。文中还介绍了在诸如哈氏病、胱氨酸尿症和亚氨基甘氨酸尿症等疾病中某些氨基酸转运的遗传障碍情况。