CD44的一种独特糖型是人造血细胞上的L-选择素配体。
A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells.
作者信息
Dimitroff C J, Lee J Y, Fuhlbrigge R C, Sackstein R
机构信息
Department of Medicine and Dermatology, Brigham and Women's Hospital and Harvard Skin Disease Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02115, USA.
出版信息
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13841-6. doi: 10.1073/pnas.250484797.
Abstract
We previously have obtained operational evidence of a hematopoietic cell L-selectin ligand expressed on normal human hematopoietic cells and on leukemic blasts. Using a technique developed in our laboratory for analyzing and identifying adhesion molecules, we show here that hematopoietic cell L-selectin ligand is a specialized glycoform of CD44. This L-selectin ligand activity of CD44 requires sialofucosylated N-linked glycans and is sulfation-independent. These data provide important insights on the structural biology of CD44 and reveal a role for this protein as an L-selectin ligand on human hematopoietic cells.
摘要
我们之前已获得在正常人造血细胞和白血病原始细胞上表达的造血细胞L-选择素配体的操作证据。利用我们实验室开发的用于分析和鉴定黏附分子的技术，我们在此表明造血细胞L-选择素配体是CD44的一种特殊糖型。CD44的这种L-选择素配体活性需要唾液酸化岩藻糖基化的N-连接聚糖，且与硫酸化无关。这些数据为CD44的结构生物学提供了重要见解，并揭示了该蛋白作为人造血细胞上L-选择素配体的作用。
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