轮状病毒疫苗：当前争议与未来方向

Rotavirus Vaccines: Current Controversies and Future Directions.

作者信息

Coffin SE

机构信息

Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.

出版信息

Curr Infect Dis Rep. 2000 Feb;2(1):68-72. doi: 10.1007/s11908-000-0090-0.

DOI:10.1007/s11908-000-0090-0

PMID:11095840

Abstract

Rotaviruses are the most important cause of pediatric gastroenteritis worldwide. In August 1998, a new rotavirus vaccine was licensed for general use in the United States. However, 14 months later, the vaccine was withdrawn from the market because of serious gastrointestinal side effects. This paper discusses the need for a rotavirus vaccine, the development of the first rotavirus vaccine, and the safety issues that led to the recall of that vaccine.

摘要

轮状病毒是全球小儿肠胃炎的最重要病因。1998年8月，一种新型轮状病毒疫苗在美国获得许可，可普遍使用。然而，14个月后，该疫苗因严重的胃肠道副作用而退出市场。本文讨论了轮状病毒疫苗的必要性、首款轮状病毒疫苗的研发，以及导致该疫苗召回的安全问题。