Beran J, De Clercq N, Dieussaert I, Van Hoecke C
Department of Epidemiology, Purkyne Military Medical Academy, Hradec Kralové, Czech Republic.
Clin Infect Dis. 2000 Dec;31(6):1504-7. doi: 10.1086/317479.
Two doses of a recombinant Lyme disease vaccine (15 and 30 microg) were administered to children 2-5 years old (0-1-month schedule) and were well tolerated. Both doses were highly immunogenic with geometric mean titers 1 month after vaccination of 4366 and 9877 ELISA units (EU)/mL, respectively. Nearly all subjects had antibody levels of > or = 1400 EU/mL, suggesting protective tick titre for one tick season.
给2至5岁的儿童（0-1月接种程序）接种了两剂重组莱姆病疫苗（15微克和30微克），耐受性良好。两剂疫苗均具有高度免疫原性，接种疫苗1个月后的几何平均滴度分别为4366和9877酶联免疫吸附测定单位（EU）/毫升。几乎所有受试者的抗体水平均≥1400 EU/毫升，表明对一个蜱虫季节具有保护性滴度。
