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城市环境中初诊腹膜透析和血液透析患者的生存情况。

Patient survival among incident peritoneal dialysis and hemodialysis patients in an urban setting.

作者信息

Tanna M M, Vonesh E F, Korbet S M

机构信息

Department of Medicine, Section of Nephrology, Rush-Presbyterian-St Lukes Medical Center, Chicago, USA.

出版信息

Am J Kidney Dis. 2000 Dec;36(6):1175-82. doi: 10.1053/ajkd.2000.19832.

Abstract

We retrospectively evaluated 432 patients (336 black; 78%; and 96 white; 22%) incident to our peritoneal dialysis (PD; 195 patients; 45%) and hemodialysis (HD; 237 patients; 55%) programs from January 1987 to December 1997 who survived their first 90 days of dialysis therapy. Black patients comprised 70% of the PD and 84% of the HD patients (P: < 0.01). PD patients were more often men and younger than HD patients and less often had diabetes (40% versus 56% of HD patients; P: < 0.01) and cardiac disease (44% versus 58% of HD patients; P: < 0.01) than HD patients. Adjusting for baseline clinical and comorbid features, patient survival was determined by Cox regression analysis. Survival was better on PD therapy overall (relative risk [RR] for PD versus HD, 0.80; 1-, 2-, and 5-year survival rates, 90%, 77%, and 43% on PD versus 88%, 72%, and 35% on HD, respectively; P: = 0.21) and among black patients (RR for PD versus HD, 0.69; 1-, 2-, and 5-year survival rates, 92%, 80%, and 52% on PD versus 88%, 74%, and 40% on HD, respectively; P: = 0.09), but these were not statistically significant. The RR for PD versus HD was 1.08 for white patients (1-, 2-, and 5-year survival rates, 82%, 61%, and 23% for PD versus 82%, 62%, and 24% for HD; P: = 0.79). Significant predictors of mortality were race (RR for whites versus blacks, 1.51), age (RR, 1.03), cardiac disease (RR, 1.57), baseline albumin level (RR, 0.60), baseline serum creatinine level (RR, 0.91), baseline blood urea nitrogen level (RR, 1.01), and baseline weight (RR, 0.98). In conclusion, patient survival on dialysis therapy is significantly better for black patients and for patients entering dialysis with signs of adequate nutrition (increased weight and creatinine and albumin levels) and without evidence of cardiac disease. In an urban dialysis program, we find that adjusted patient survival on PD equals or is better than that on HD therapy, particularly among black patients, making PD a viable alternative to HD in our patient population.

摘要

我们回顾性评估了1987年1月至1997年12月期间在我们腹膜透析(PD;195例患者;45%)和血液透析(HD;237例患者;55%)项目中开始透析治疗且存活度过最初90天的432例患者(336例黑人;78%;96例白人;22%)。黑人患者占PD患者的70%,占HD患者的84%(P:<0.01)。PD患者男性比例更高且比HD患者年轻,患糖尿病(分别为HD患者的40%对56%;P:<0.01)和心脏病(分别为HD患者的44%对58%;P:<0.01)的比例低于HD患者。对基线临床和合并症特征进行调整后,通过Cox回归分析确定患者生存率。总体而言,PD治疗的生存率更高(PD与HD相比的相对风险[RR]为0.80;1年、2年和5年生存率,PD分别为90%、77%和43%,HD分别为88%、72%和35%;P:=0.21),在黑人患者中也是如此(PD与HD相比的RR为0.69;1年、2年和5年生存率,PD分别为92%、80%和52%,HD分别为88%、74%和40%;P:=0.09),但这些差异无统计学意义。白人患者中PD与HD相比的RR为1.08(1年、2年和5年生存率,PD分别为82%、61%和23%,HD分别为82%、62%和24%;P:=0.79)。死亡率的显著预测因素包括种族(白人对黑人的RR为1.51)、年龄(RR为1.03)、心脏病(RR为1.57)、基线白蛋白水平(RR为0.60)、基线血清肌酐水平(RR为0.91)、基线血尿素氮水平(RR为1.01)和基线体重(RR为0.98)。总之,黑人患者以及开始透析时具有充足营养迹象(体重、肌酐和白蛋白水平升高)且无心脏病证据的患者,透析治疗的生存率显著更高。在一个城市透析项目中,我们发现调整后的PD患者生存率等于或优于HD治疗,尤其是在黑人患者中,这使得PD在我们的患者群体中成为HD的可行替代方案。

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