Costello L C, Franklin R B
Cellular and Molecular Biology Section, OCBS/Dental School, University of Maryland, Baltimore, MD, USA.
Oncology. 2000 Nov;59(4):269-82. doi: 10.1159/000012183.
This review emphasizes the importance and role of altered intermediary metabolism of prostate cells in the pathogenesis of prostate adenocarcinoma (PCa) and the progression of malignancy. The focus of the presentation is a summary of the overwhelming evidence which implicates the metabolic transformation of citrate-producing sane cells to citrate-oxidizing malignant cells in the process of malignancy. The evidence now demonstrates that altered zinc accumulation is an important factor in this transformation. These metabolic relationships are uniquely different from the metabolic alterations associated with tumorigenesis of other mammalian cells. The metabolic transformation of zinc-accumulating citrate-producing normal prostate epithelial cells to citrate-oxidizing malignant cells has important implications on cellular bioenergetics, cell growth and apoptosis, lipogenesis, angiogenesis. Based on the metabolic considerations new concepts concerning the pathogenesis, diagnosis and treatment of prostate malignancy are presented. Unfortunately the metabolism of the prostate has been a seriously neglected and largely ignored area of prostate research. The importance of expanded research into the intermediary metabolism of normal and neoplastic prostate is essential to future significant advances in understanding and dealing with PCa.
本综述强调前列腺细胞中间代谢改变在前列腺腺癌（PCa）发病机制及恶性进展中的重要性和作用。报告重点总结了大量证据，这些证据表明在恶性过程中，产生柠檬酸盐的正常细胞向氧化柠檬酸盐的恶性细胞发生了代谢转变。目前的证据表明，锌积累的改变是这一转变的重要因素。这些代谢关系与其他哺乳动物细胞肿瘤发生相关的代谢改变截然不同。积累锌并产生柠檬酸盐的正常前列腺上皮细胞向氧化柠檬酸盐的恶性细胞的代谢转变，对细胞生物能量学、细胞生长与凋亡、脂肪生成、血管生成具有重要意义。基于代谢方面的考虑，提出了有关前列腺恶性肿瘤发病机制、诊断和治疗的新概念。遗憾的是，前列腺代谢一直是前列腺研究中严重被忽视且大多被忽略的领域。扩大对正常和肿瘤性前列腺中间代谢的研究，对于未来在理解和处理PCa方面取得重大进展至关重要。
