Villa E A, Marx G F
Can Anaesth Soc J. 1975 Jan;22(1):76-8. doi: 10.1007/BF03004821.
Two case reports, one a vaginal delivery, the other a Caesarean Section, have been presented to demonstrate the rationale of employing a chloroprocaine-bupivacaine sequence for extradural analgesia in obstetrics. Use of chloroprocaine for initiation and bupivacaine for maintenance of the block offers at least three advantages: (1) onset of pain relief is prompt while duration is prolonged; (2) more than one "test" dose of chloroprocaine may be employed with safety in rapid succession; (3) two drugs with different metabolic patterns are used, each in reduced amount.
现呈现两例病例报告，一例为阴道分娩，另一例为剖宫产，以阐述在产科硬膜外镇痛中采用氯普鲁卡因 - 布比卡因序贯给药的基本原理。使用氯普鲁卡因起始阻滞并使用布比卡因维持阻滞至少具有三个优点：（1）疼痛缓解起效迅速且持续时间延长；（2）可安全地连续快速使用超过一剂氯普鲁卡因“试验”剂量；（3）使用了两种代谢模式不同的药物，且每种药物用量减少。
