Cramer L G, Pitt S R, Rehbein S, Gogolewski R P, Kunkle B N, Langhoff W K, Bond K G, Maciel A E
Merial Ltd, Iselin, NJ 08830-3077, USA.
Parasitol Res. 2000 Nov;86(11):944-6. doi: 10.1007/s436-000-8011-z.
Six studies were conducted to evaluate the persistent efficacy of eprinomectin pour-on against experimental challenges with infective nematode larvae in calves. In each study, calves were randomly assigned to one untreated group and up to four test groups, which were treated with eprinomectin at 500 microg/kg body weight at weekly intervals before single bolus challenge. The calves were necropsied approximately 4 weeks after challenge infection for nematode recovery. Eprinomectin pour-on provided > or =90% efficacy against challenge with Haemonchus placei, Trichostrongylus axei and T. colubriformis at 21 days after treatment and against Cooperia oncophora, C. punctata, C. surnabada, Dictyocaulus viviparus, Nematodirus helvetianus, Oesophagostomum radiatum and Ostertagia ostertagi at 28 days after treatment.
开展了六项研究，以评估埃普利诺菌素浇泼剂对犊牛感染性线虫幼虫实验性攻击的持续效力。在每项研究中，犊牛被随机分为一个未处理组和多达四个试验组，在单次大剂量攻击前，试验组每周按500微克/千克体重的剂量用埃普利诺菌素进行处理。在攻击感染后约4周对犊牛进行剖检以回收线虫。埃普利诺菌素浇泼剂在治疗后21天对感染巴氏血矛线虫、斧形毛圆线虫和蛇形毛圆线虫的攻击效力≥90%，在治疗后28天对感染胎生网尾线虫、粗纹库珀线虫、点状库珀线虫、苏氏库珀线虫、瑞士细颈线虫、辐射食道口线虫和奥氏奥斯特线虫的攻击效力≥90%。
