Jakobsen A
Department of Oncology, Vejle Hospital, Denmark.
Oncology (Williston Park). 2000 Oct;14(10 Suppl 9):32-4.
UFT is an investigational agent that may be useful treatment for colorectal carcinoma and other cancers for which fluorinated pyrimidines are a useful treatment. The combination of continuous-infusion fluorouracil (5-FU) with leucovorin and mitomycin-C can significantly delay recurrence and may prolong life. UFT may be an attractive alternative to continuous-infusion 5-FU because three-times-daily administration of UFT results in comparable concentrations of 5-FU in the plasma. Recently, a clinical trial investigated the combination of UFT and mitomycin-C and found it demonstrated significant synergy in the treatment of advanced colorectal cancer. We describe the design of a phase II study to investigate the safety and efficacy of UFT/leucovorin combined with mitomycin-C in a larger group of previously untreated patients with metastatic colorectal cancer.
优福定（UFT）是一种试验性药物，对于结直肠癌和其他可用氟嘧啶有效治疗的癌症可能是一种有用的治疗方法。持续输注氟尿嘧啶（5-FU）与亚叶酸和丝裂霉素-C联合使用可显著延迟复发并可能延长生命。优福定可能是持续输注5-FU的一个有吸引力的替代方案，因为优福定每日三次给药可使血浆中5-FU的浓度相当。最近，一项临床试验研究了优福定与丝裂霉素-C的联合使用，发现其在晚期结直肠癌的治疗中显示出显著的协同作用。我们描述了一项II期研究的设计，以调查优福定/亚叶酸联合丝裂霉素-C在更大规模的先前未接受治疗的转移性结直肠癌患者中的安全性和有效性。
