Yamada K, Kaga K, Tsuzuku T, Uno A
Department of Otolaryngology, Teikyo University School of Medicine, Japan.
Acta Otolaryngol. 2000 Sep;120(6):744-9. doi: 10.1080/000164800750000289.
Short- and long-term changes in the middle latency response (MLR) after bilateral ablation of the auditory cortices were studied in awake cats. The amplitude of the negative peak with a latency of about 15 ms (NA) decreased to 60% of the original value 1 week after ablation (short-term change). In the long term, i.e. 11-30 months, NA either decreased further (decreased group) or remained unchanged (non-decreased group). A histological study with light microscopy revealed degeneration of neurons in the ventral nucleus of the medial geniculate body (MGv) in the decreased group, whereas the neurons in this region were preserved in the non-decreased group. This study suggests that long-term changes in NA reflect retrograde degeneration in the MGv after auditory cortical ablation.
在清醒的猫身上研究了双侧听觉皮层切除术后中潜伏期反应（MLR）的短期和长期变化。潜伏期约为15毫秒的负峰（NA）幅度在切除术后1周降至原始值的60%（短期变化）。从长期来看，即11 - 30个月，NA要么进一步降低（降低组），要么保持不变（未降低组）。光学显微镜组织学研究显示，降低组的内侧膝状体腹侧核（MGv）中的神经元发生了退化，而在未降低组中该区域的神经元得以保留。这项研究表明，NA的长期变化反映了听觉皮层切除术后MGv中的逆行性退化。
