Sawada T, Aono M, Asakawa S, Ito A, Awano K
Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd., Nogi-machi, Tochigi, Japan.
J Antibiot (Tokyo). 2000 Sep;53(9):959-66. doi: 10.7164/antibiotics.53.959.
A novel antibacterial substance, AB0022A, was isolated from the cellular slime mold Dictyostelium purpureum K1001. It inhibited the growth of Gram-positive bacteria, and its MICs ranged from 0.39 to 50 microg/ml. Because AB0022A was a highly substituted aromatic compound, we could not determine its structure based on only its physico-chemical and spectral data. We therefore used a dehalogenated derivative from AB0022A and deduced that its structure was 1,9-dihydroxy-3,7-dimethoxy-2-hexanoyl-4,6,8-trichlorodibenzofuran . To confirm this structure, we synthesized the compound having the deduced structure. The synthetic compound was identical to naturally occurring AB0022A.
