Liu Z, Murray E A, Richmond B J
Laboratory of Neuropsychology, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892, USA.
Nat Neurosci. 2000 Dec;3(12):1307-15. doi: 10.1038/81841.
The limbic system is necessary to associate stimuli with their motivational and emotional significance. The perirhinal cortex is directly connected to this system, and neurons in this region carry signals related to a monkey's progress through visually cued reward schedules. This task manipulates motivation by displaying different visual cues to indicate the amount of work remaining until reward delivery. We asked whether rhinal (that is, entorhinal and perirhinal) cortex is necessary to associate the visual cues with reward schedules. When faced with new visual cues in reward schedules, intact monkeys adjusted their motivation in the schedules, whereas monkeys with rhinal cortex removals failed to do so. Thus, the rhinal cortex is critical for forming associations between visual stimuli and their motivational significance.
边缘系统对于将刺激与其动机和情感意义联系起来是必要的。嗅周皮质直接与该系统相连，该区域的神经元携带与猴子在视觉线索奖励计划中的进展相关的信号。这项任务通过显示不同的视觉线索来操纵动机，以表明在奖励发放之前剩余的工作量。我们询问嗅皮质（即内嗅皮质和嗅周皮质）对于将视觉线索与奖励计划联系起来是否必要。当在奖励计划中面对新的视觉线索时，完整的猴子会在计划中调整它们的动机，而切除嗅皮质的猴子则无法做到这一点。因此，嗅皮质对于形成视觉刺激与其动机意义之间的关联至关重要。
