Zhou B B, Elledge S J
Department of Oncology Research, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.
Nature. 2000 Nov 23;408(6811):433-9. doi: 10.1038/35044005.
The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.
哺乳动物中DNA损伤修复功能的缺陷会导致多种疾病，并提高肿瘤发生几率。生物体通过激活复杂的损伤反应途径来应对染色体损伤。该途径调控诸如细胞周期停滞和凋亡（程序性细胞死亡）等已知反应，并且最近研究表明它还能控制包括直接激活DNA修复网络在内的其他过程。
