Sanford L M, Moore C, Voglmayr J K, Fahmy M H
Department of Animal Science, McGill University, Ste Anne de Bellevue, Québec, Canada .
Theriogenology. 2000 Sep 15;54(5):719-30. doi: 10.1016/s0093-691x(00)00385-x.
Developmental patterns in immunoactive inhibin and FSH concentrations in peripheral blood were determined for Suffolk and DLS (Dorset x Leicester x Suffolk) rams born in January Blood samples were taken every 3 to 4 wk when testes were developing during puberty (5 to 44 wk of age) and redeveloping in early adulthood (17 to 23 months of age). Suffolk lambs had a greater average daily gain (195 vs. 143 g/day, P<0.01), and they developed larger testes (P<0.01) than DLS lambs. Inhibin and FSH concentrations peaked at about the same pubertal (8 wk) and early adult (19 or 20 months) ages in both breeds. Elevations in FSH were greater (P< 0.05) in Suffolk than DLS rams at each stage of development. The pubertal inhibin peak was nearly 70% larger (P<0.01) in DLS than Suffolk rams, and the early adult peak was comparable in rams of both breeds, but much smaller (P<0.01) than the pubertal peak. Nonetheless, inhibin was positively correlated (r=0.48 to 0.57) with FSH in both breeds during each developmental stage. Inhibin and testicular size were negatively correlated in Suffolk (r=-0.74) and DLS (r=-0.86) rams during puberty, and positively correlated in DLS rams (r=0.46) in early adulthood. We conclude that 1) inhibin concentrations are higher in juvenile rams at the time Sertoli cell numbers are being established than in adult rams during testicular recrudescence and 2) rises in FSH concentration participate in regulating corresponding rises in inhibin concentration in both stages of testicular development.
测定了1月份出生的萨福克公羊和DLS（多塞特×莱斯特×萨福克）公羊外周血中免疫活性抑制素和促卵泡激素（FSH）浓度的发育模式。在青春期（5至44周龄）睾丸发育以及成年早期（17至23月龄）睾丸再次发育期间，每隔3至4周采集一次血样。萨福克羔羊的平均日增重更高（195克/天对143克/天，P<0.01），且其睾丸比DLS羔羊发育得更大（P<0.01）。两个品种的抑制素和FSH浓度在青春期（8周）和成年早期（19或20个月）达到峰值的时间大致相同。在每个发育阶段，萨福克公羊FSH的升高幅度均大于DLS公羊（P<0.05）。DLS公羊青春期抑制素峰值比萨福克公羊大近70%（P<0.01），两个品种成年早期的峰值相当，但比青春期峰值小得多（P<0.01）。尽管如此，在每个发育阶段，两个品种的抑制素与FSH均呈正相关（r=0.48至0.57）。在青春期，萨福克公羊（r=-0.74）和DLS公羊（r=-0.86）的抑制素与睾丸大小呈负相关，而在成年早期，DLS公羊的抑制素与睾丸大小呈正相关（r=0.46）。我们得出结论：1）在支持细胞数量确立时，幼年公羊的抑制素浓度高于成年公羊睾丸再生期的抑制素浓度；2）在睾丸发育的两个阶段，FSH浓度的升高参与调节抑制素浓度的相应升高。
