Present difficulties and future promise of MHC multimers in autoimmune exploration.
作者信息
Ferlin W, Glaichenhaus N, Mougneau E
机构信息
Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, 660 Route des Lucioles, 06560 Valbonne, France.
出版信息
Curr Opin Immunol. 2000 Dec;12(6):670-5. doi: 10.1016/s0952-7915(00)00161-8.
Abstract
Class I tetramers have been used to track cytotoxic T cells during bacterial and viral infections. During the past year, the use of such molecules has revealed important information about the role of CD8(+) T cells in autoimmune diabetes. Furthermore, class II multimers have been produced and successfully used to stain autoreactive CD4(+) T cells from patients with rheumatoid arthritis or Borrelia-burgdorferi-induced Lyme arthritis.
摘要
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