自身免疫性疾病的抗原特异性疗法。

Antigen-specific therapy for autoimmune disease.

作者信息

Harrison L C, Hafler D A

机构信息

Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville 3050, Australia.

出版信息

Curr Opin Immunol. 2000 Dec;12(6):704-11. doi: 10.1016/s0952-7915(00)00166-7.

DOI:10.1016/s0952-7915(00)00166-7

PMID:11102776

Abstract

The application of self-antigens as therapeutic tools is validated in inbred animal models of autoimmune disease. Mechanisms of antigen-induced tolerance (apoptosis, anergy, regulatory T cells and immune deviation) are being clarified in relation to the properties of antigens and the modes and routes of their delivery. Mucosa-mediated tolerance remains the predominant mode of antigen-specific therapy but awaits demonstration of clinical efficacy in human autoimmune disease.

摘要

自身抗原作为治疗工具在自身免疫性疾病的近交系动物模型中得到了验证。抗原诱导耐受的机制（细胞凋亡、无反应性、调节性T细胞和免疫偏离）正根据抗原的特性及其递送方式和途径进行阐明。黏膜介导的耐受仍然是抗原特异性治疗的主要模式，但有待在人类自身免疫性疾病中证明其临床疗效。