Miller Stephen D, Turley Danielle M, Podojil Joseph R
Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Nat Rev Immunol. 2007 Sep;7(9):665-77. doi: 10.1038/nri2153. Epub 2007 Aug 10.
The development of safe and effective antigen-specific therapies is needed to treat patients with autoimmune diseases. These therapies must allow for the specific tolerization of self-reactive immune cells without altering host immunity to infectious insults. Experimental models and clinical trials for the treatment of autoimmune disease have identified putative mechanisms by which antigen-specific therapies induce tolerance. Although advances have been made in the development of efficient antigen-specific therapies, translating these therapies from bench to bedside has remained difficult. Here, we discuss the recent advances in our understanding of antigen-specific therapies for the treatment of autoimmune diseases.
需要开发安全有效的抗原特异性疗法来治疗自身免疫性疾病患者。这些疗法必须能够使自身反应性免疫细胞产生特异性耐受，同时又不改变宿主对感染性侵害的免疫力。治疗自身免疫性疾病的实验模型和临床试验已经确定了抗原特异性疗法诱导耐受的推定机制。尽管在高效抗原特异性疗法的开发方面已经取得了进展，但将这些疗法从实验室转化到临床应用仍然困难重重。在此，我们讨论了在理解用于治疗自身免疫性疾病的抗原特异性疗法方面的最新进展。
