Ferrara N
Department of Molecular Oncology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Curr Opin Biotechnol. 2000 Dec;11(6):617-24. doi: 10.1016/s0958-1669(00)00153-1.
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that the inhibition of VEGF activity may be beneficial for these conditions.
血管内皮生长因子（VEGF）是一种内皮细胞特异性有丝分裂原、血管生成诱导剂以及血管通透性介质。VEGF对发育性血管生成至关重要，对女性生殖功能和软骨内骨形成也必不可少。大量证据还表明VEGF与肿瘤和眼内新生血管综合征有关。目前，正在进行多项临床试验以验证抑制VEGF活性可能对这些病症有益这一假说。
