Ferreira SM, Ferreira AG, Furlan IM, Furlan A, Gomes Md, Santos EO, Linhares AC, Décourt LV
Luiz Décourt Foundation.
Braz J Infect Dis. 1998 Oct;2(5):256-259.
We studied four children who were born with congenital rubella syndrome, in whom cardiac malformations including semilunar valvar stenosis were present. These children attended the Pediatric Cardiology Unit of Hospital Fundação Santa Casa de Misericórdia do Pará. The diagnosis was made clinically and by laboratory results. Specific anti-rubella antibodies IgM and IgG were measured using a capture-antibody enzyme immunoassay. Three patients presented with aortic stenosis associated with patient ductus arteriosus, and 1 patient had isolated pulmonary valvar stenosis. Rubella-specific IgM antibodies were detected in 3 of the 4 children and IgG antibodies in 1. We review the role of rubella virus as a teratogenic agent implicated in a pathogenesis of aortic and pulmonary valvar stenosis. These pathologic lesion are part of the diffuse ateriopathy that affects the fetus with rubella virus infection.
我们研究了4名患有先天性风疹综合征的儿童，他们存在包括半月瓣狭窄在内的心脏畸形。这些儿童在帕拉州圣卡塔琳娜慈善医院儿科心脏病科就诊。诊断通过临床症状和实验室检查结果得出。使用捕获抗体酶免疫测定法检测特异性抗风疹抗体IgM和IgG。3例患者表现为主动脉狭窄合并动脉导管未闭，1例患者为单纯肺动脉瓣狭窄。4名儿童中有3名检测到风疹特异性IgM抗体，1名检测到IgG抗体。我们回顾了风疹病毒作为致畸原在主动脉和肺动脉瓣狭窄发病机制中的作用。这些病理病变是风疹病毒感染胎儿时所发生的弥漫性动脉病变的一部分。
