有明显危及生命事件的婴儿的心率变异性

Heart rate variability in infants with apparent life-threatening events.

作者信息

Edner A, Katz-Salamon M, Lagercrantz H, Ericson M, Milerad J

机构信息

Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden.

出版信息

Acta Paediatr. 2000 Nov;89(11):1326-9. doi: 10.1080/080352500300002516.

DOI:10.1080/080352500300002516

PMID:11106044

Abstract

UNLABELLED

Heart rate variability (HRV) is often used as an index of sympatho-vagal balance. A decreased HRV has been observed in patients with central hypoventilation and in infants who have later succumbed to sudden infant death syndrome (SIDS). The aim of the present study was to investigate whether HRV is altered in infants with apparent life-threatening events (ALTE), a group with an increased risk of SIDS. Fifty infants with ALTE were compared with 50 age- and sex-matched controls. ECG was recorded overnight in all infants. Two sequences of RR intervals free of artefacts were selected from each sleep state and spectral analysis of RR variability was performed. The mean and SD of RR and the low (LFPow) and high (HFPow) frequency power were analysed. In active sleep (AS) the LF/HF ratio was lower in ALTE infants, but no differences were seen in either the LFPow or the HFPow. In quiet sleep (QS), however, ALTE infants had higher SD-RR (p = 0.006), greater HFPow (p = 0.02) and VLFPow (very low frequency power, p = 0.02) than the control infants. The same results were seen when the two sleep states were combined for analysis, ALTE infants had higher SD-RR (p = 0.004), HFPow (p = 0.006) and VLFPow (p = 0.04).

CONCLUSION

The different HRV pattern in ALTE infants compared to healthy controls suggests an altered autonomic control.

摘要

未标注

心率变异性（HRV）常被用作交感 - 迷走神经平衡的指标。在中枢性通气不足的患者以及后来死于婴儿猝死综合征（SIDS）的婴儿中观察到HRV降低。本研究的目的是调查患有明显危及生命事件（ALTE）的婴儿（这是一个SIDS风险增加的群体）的HRV是否发生改变。将50名患有ALTE的婴儿与50名年龄和性别匹配的对照组进行比较。所有婴儿均进行了整夜心电图记录。从每个睡眠状态中选择两个无伪迹的RR间期序列，并对RR变异性进行频谱分析。分析了RR的均值和标准差以及低频（LFPow）和高频（HFPow）功率。在主动睡眠（AS）中，ALTE婴儿的LF/HF比值较低，但在LFPow或HFPow方面均未观察到差异。然而，在安静睡眠（QS）中，ALTE婴儿的SD - RR更高（p = 0.006），HFPow更大（p = 0.02），极低频功率（VLFPow，p = 0.02）也比对照婴儿更高。当将两种睡眠状态合并进行分析时，得到了相同的结果，ALTE婴儿的SD - RR更高（p = 0.004），HFPow更高（p = 0.006），VLFPow更高（p = 0.04）。