[白细胞介素-18与新药。对肿瘤生长和感染的保护作用]
[Interleukin-18 and new drugs. Protective effect against tumor growth and infections].
作者信息
Wollheim F A
机构信息
Reumatologiska kliniken, Universitetssjukhuset i Lund.
出版信息
Lakartidningen. 2000 Oct 11;97(41):4604.
IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure as well as its processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. A summary is made of recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions. It focuses on the role of IL-18 modulation in tumours, infections and autoimmune and inflammatory diseases.
白细胞介素-18最初被鉴定为γ-干扰素诱导因子（IGIF），就其结构、加工、受体、信号转导途径和促炎特性而言，与白细胞介素-1家族相关。白细胞介素-18在功能上也与白细胞介素-12相关，因为它可诱导Th1细胞因子的产生并参与细胞介导的免疫细胞毒性。本文总结了在理解白细胞介素-18结构、加工、受体表达和免疫调节功能方面的最新进展。重点关注白细胞介素-18调节在肿瘤、感染以及自身免疫和炎症性疾病中的作用。
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