Lebel-Binay S, Berger A, Zinzindohoué F, Cugnenc P, Thiounn N, Fridman W H, Pagès F
Luti/Laboratoire de Recherche Chirurgicale, Bât. Gustave-Roussy, 3e étage, Hôpital Cochin, 27, rue du Faubourg-St-Jacques, 75014 Paris, France.
Eur Cytokine Netw. 2000 Mar;11(1):15-26.
IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases.
白细胞介素-18最初被鉴定为γ-干扰素诱导因子（IGIF），就其结构、加工、受体、信号转导途径和促炎特性而言，与白细胞介素-1家族相关。白细胞介素-18在功能上也与白细胞介素-12相关，因为它可诱导Th1细胞因子的产生并参与细胞介导的免疫细胞毒性。本综述总结了在理解白细胞介素-18结构、加工、受体表达和免疫调节功能方面的最新进展，并重点关注白细胞介素-18调节在肿瘤、感染以及自身免疫和炎症性疾病中的作用。
