Beaman-Mbaya V, Ogola E N
Department of Biochemistry, University of Nairobi, Kenya.
Ethn Dis. 2000 Autumn;10(3):357-63.
This pilot project studies the prevalence of hypertension among unique social groups in Kenya, as well as the hormonal profiles accompanying the hypertensive and normotensive states in these populations. The purpose of this report is to enlarge and improve upon the statistical data currently available concerning the prevalence, etiology and prognosis of hypertensive disease in this region. In this study, the urinary concentrations of three vasoactive metabolites were measured in hypertensive and normotensive outpatients. The excretion values for the metabolites were ultimately tabulated as the quantity excreted per milligram of creatinine. The results demonstrate that the subjects with elevated blood pressures (>140/90 mm Hg) excreted double the concentrations (ng/mg creatinine) of cortisol and aldosterone excreted by normotensives. There were no apparent differences in urinary catecholamines between hypertensives and normotensives.
这个试点项目研究了肯尼亚独特社会群体中高血压的患病率，以及这些人群中高血压和正常血压状态所伴随的激素水平。本报告的目的是扩充和完善目前关于该地区高血压疾病患病率、病因和预后的统计数据。在这项研究中，测量了高血压和正常血压门诊患者尿液中三种血管活性代谢物的浓度。代谢物的排泄值最终以每毫克肌酐排泄量的形式列表。结果表明，血压升高（>140/90毫米汞柱）的受试者排泄的皮质醇和醛固酮浓度（纳克/毫克肌酐）是正常血压者的两倍。高血压患者和正常血压患者尿液中的儿茶酚胺没有明显差异。
