2,3-二磷酸甘油酸：血小板聚集的生理抑制剂。

2,3-diphosphoglycerate: a physiological inhibitor of platelet aggregation.

作者信息

Iatridis S G, Iatridis P G, Markidou S G, Ragatz B H

出版信息

Science. 1975 Jan 24;187(4173):259-61. doi: 10.1126/science.1111100.

Abstract

2,3-Diphosphoglycerate (2,3-DPG) may inhibit the platelet release reaction and the irreversible aggregation of human blood platelets induced by adenosine diphosphate, epinephrine, or norepinephrine. The effects of 2,3-DPG on platelet aggregation were more pronounced in cases with low hematocrit (less than 30 percent). Dipyridamole and vincaminor potentiated the antiaggregating effect of 2,3-DPG. Erythocytes (10-3 to 10-4 per microliter) exhibited a similar antiaggregating effect, especially when secured from anemic patients.

摘要

2,3-二磷酸甘油酸（2,3-DPG）可能抑制血小板释放反应以及由二磷酸腺苷、肾上腺素或去甲肾上腺素诱导的人血小板不可逆聚集。2,3-DPG对血小板聚集的影响在血细胞比容低（低于30%）的情况下更为明显。双嘧达莫和长春胺增强了2,3-DPG的抗聚集作用。红细胞（每微升10⁻³至10⁻⁴个）表现出类似的抗聚集作用，尤其是从贫血患者获取的红细胞。