Conrad C, Steffen T, Gutzwiller F
Institut für Suchtforschung, Zürich.
Praxis (Bern 1994). 2000 Nov 16;89(46):1899-906.
Drug addiction is linked with increased prevalence of various illnesses. Of major importance are skin diseases which often have a powerful influence on the health. Analysis of the situation in Switzerland at the outset of the 1990s showed that not all drug addicts could be reached with the existing range of treatments. For this reason, heroin-supported treatment was examined as a new therapy option from 1994 on. The influence on the skin's health are examined in this study. The minimum age of those admitted was set at age 20. Heroin addiction had to date back at least two years, and several treatment efforts had to have failed. Data of 1,035 patients was based on tests at admission and after six, 12, and 18 months of treatment. Some 18% of drug consumers indicated abcesses at admission, and almost 30% showed phlegmones. The prevalence of all skin diseases examined show significant declines over the 18 months of treatment. The relative risk resulting from puncture points fell to 0.35 (SD: 0.26-0.47), from phlegmones to 0.24 (SD: 0.14-0.41), from absesses to 0.31 (SD: 0.15-0.60). This study shows that skin diseases are a frequent and important complication among intravenous drug addicts. Heroin-supported treatment led to favourable progress of the dermatological situation among patients.
药物成瘾与各种疾病患病率的增加有关。其中最重要的是皮肤病，这些疾病往往对健康有很大影响。对20世纪90年代初瑞士情况的分析表明，现有的治疗方法并不能覆盖所有的药物成瘾者。因此，从1994年起，对海洛因辅助治疗作为一种新的治疗选择进行了研究。本研究考察了其对皮肤健康的影响。入院者的最低年龄设定为20岁。海洛因成瘾必须至少追溯到两年前，并且此前的几次治疗尝试均告失败。1035名患者的数据基于入院时以及治疗6个月、12个月和18个月后的检测结果。约18%的吸毒者在入院时出现脓肿，近30%出现蜂窝织炎。在18个月的治疗期间，所有检查的皮肤病患病率均显著下降。穿刺点导致的相对风险降至0.35（标准差：0.26 - 0.47），蜂窝织炎降至0.24（标准差：0.14 - 0.41），脓肿降至0.31（标准差：0.15 - 0.60）。本研究表明，皮肤病是静脉注射吸毒者中常见且重要的并发症。海洛因辅助治疗使患者的皮肤病状况取得了良好进展。
