Shimmura H, Tanabe K, Ishikawa N, Tokumoto T, Fuchinoue S, Takahashi K, Toma H, Agishi T
Department of Urology, Kidney Center, Tokyo Women's Medical University, Japan.
Ther Apher. 2000 Oct;4(5):395-8. doi: 10.1046/j.1526-0968.2000.004005395.x.
Because of a shortage of cadaver donors in Japan, ABO-incompatible living kidney transplantation has been carried out. Sixty-seven ABO-incompatible living kidney transplantations (LKT) were performed between January 1989 and December 1995 at our institution. In our previous report on the long-term results of ABO-incompatible LKT, graft survival of ABO-incompatible LKT up to 3 years was significantly lower than that of ABO-compatible LKT, but no significant difference was seen from 4 to 8 years. We removed anti-A/B antibodies by immunoadsorption and/or double filtration plasmapheresis before kidney transplantation. There was a significant difference between the anti-A/B antibody titers before and after plasmapheresis. The anti-A/B antibody titers also were well suppressed over the long term after transplantation.
由于日本尸体供体短缺，已开展ABO血型不相容的活体肾移植。1989年1月至1995年12月期间，我们机构进行了67例ABO血型不相容的活体肾移植（LKT）。在我们之前关于ABO血型不相容LKT长期结果的报告中，ABO血型不相容LKT至3年的移植物存活率显著低于ABO血型相容LKT，但4至8年时未见显著差异。我们在肾移植前通过免疫吸附和/或双重过滤血浆置换去除抗A/B抗体。血浆置换前后抗A/B抗体滴度存在显著差异。移植后抗A/B抗体滴度长期也得到良好抑制。
