Check M L, Check J H, Katsoff D, Summers-Chase D
The University of Medicine/Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
Arch Androl. 2000 Nov-Dec;45(3):125-30. doi: 10.1080/01485010050193887.
This study was conducted to evaluate if in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI) is an effective treatment for infertility complicated by the presence in the male partner of sperm autoantibodies. Over a 1-year study period comparisons of fertilization, pregnancy, and implantation rates were made in couples where the male partner was negative or weakly positive for sperm autoantibodies (<50%) (gr 1); autoantibodies were strongly positive (>80%) (gr 2); or autoantibodies were moderately positive (50-80%) (gr 3). Only patients having oocytes fertilized by ICSI were included. The fertilization, clinical pregnancy, implantation, and miscarriage rate for group 1 (n = 67) was 56, 43, 21, and 14%. Comparable values for group 2 (n = 20) were 55, 40, 23, and 25%, and for group 3 (n = 6) were 63, 33, 23, and 0%. IVF with ICSI demonstrates comparable fertilization, pregnancy, implantation, and miscarriage rates in female partners of males with and without sperm autoantibodies.
本研究旨在评估体外受精（IVF）联合卵胞浆内单精子注射（ICSI）是否是治疗因男性伴侣存在精子自身抗体而并发的不孕症的有效方法。在为期1年的研究期间，对男性伴侣精子自身抗体呈阴性或弱阳性（<50%）（第1组）、自身抗体呈强阳性（>80%）（第2组）或自身抗体呈中度阳性（50 - 80%）（第3组）的夫妇的受精、妊娠和着床率进行了比较。仅纳入通过ICSI使卵母细胞受精的患者。第1组（n = 67）的受精率、临床妊娠率、着床率和流产率分别为56%、43%、21%和14%。第2组（n = 20）的相应值分别为55%、40%、23%和25%，第3组（n = 6）的相应值分别为63%、33%、23%和0%。ICSI联合IVF显示，男性有或没有精子自身抗体的女性伴侣在受精、妊娠、着床和流产率方面具有可比性。
