Mackowiak P A
Medical Care Clinical Center, VA Maryland Health Care System and Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Clin Infect Dis. 2000 Oct;31 Suppl 5:S230-3. doi: 10.1086/317512.
It has been suggested that the response to antipyretic therapy might differentiate between fevers due to serious illness and fevers caused by less severe disorders; that neoplastic fevers are more responsive to nonsteroidal anti-inflammatory drugs than are infectious fevers; that the metabolic costs of fever can exceeds its clinical benefits; that antipyretic therapy can prevent or reverse febrile seizures in children and fever-associated mental dysfunction in frail elderly patients. This article examines the data on which these assertions are based.
有人提出，对退热治疗的反应可能有助于区分由严重疾病引起的发热和由不太严重的病症引起的发热；肿瘤性发热比感染性发热对非甾体抗炎药更敏感；发热的代谢成本可能超过其临床益处；退热治疗可以预防或逆转儿童的热性惊厥以及体弱老年患者与发热相关的精神功能障碍。本文将审视这些论断所依据的数据。
