Watanabe K, Takeda K, Katori Y, Ikeda K, Oshima T, Yasumoto K, Saito H, Takasaka T, Shibahara S
Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
Brain Res Mol Brain Res. 2000 Dec 8;84(1-2):141-5. doi: 10.1016/s0169-328x(00)00236-9.
Mutations in the SOX10 gene, encoding a cell-lineage specific transcription factor, are associated with congenital deafness. We analyzed the expression of Sox10 mRNA in developing mouse inner ear by in situ hybridization. Sox10 mRNA is expressed in the entire epithelia of the otic vesicle at embryonic day 11.5 (E11.5) and in the developing cochlea and vestibule at E13.5. In postnatal day 8 and adult cochleas, Sox10 expression is restricted to the supporting cells of the organ of Corti. These expression profiles suggest that Sox10 is important for development of the cochlea.
编码细胞谱系特异性转录因子的SOX10基因突变与先天性耳聋有关。我们通过原位杂交分析了发育中小鼠内耳中Sox10 mRNA的表达。Sox10 mRNA在胚胎第11.5天（E11.5）的耳泡全层上皮中表达，并在E13.5时在发育中的耳蜗和前庭中表达。在出生后第8天和成年耳蜗中，Sox10的表达局限于柯蒂氏器的支持细胞。这些表达谱表明Sox10对耳蜗发育很重要。
