Garossino K C, Ralston B J, McAllister T A, Milligan D N, Royan G, Olson M E
Gastrointestinal Research Group, University of Calgary, Alta. T2N 4N1, Canada.
Vet Parasitol. 2001 Jan 1;94(3):151-62. doi: 10.1016/s0304-4017(00)00380-0.
The current study was conducted to assess the feasibility of fenbendazole (FB) administration to steers in a free choice mineral supplement. Provision of free choice FB reduces the need for handling of animals as well as decreases the level of animal parasitism. Two separate trials were conducted using 400 +/- 19 kg Holstein steers (n=14 and 17) during the months of July and August. Each steer was tagged with a unique electronic identification (EID) ear tag and randomly allocated into one of two groups. The tags worked in conjunction with a mineral feeder equipped with a load cell by registering the steer's EID number every time the animal entered the electromagnetic field. Individual daily mineral intake and feeding times were determined over two 8-day periods of non-medicated mineral (no FB), separated by a 14-day period of medicated mineral (0.55% FB). Fecal samples were collected at the beginning and end of each trial period and were analyzed for gastrointestinal nematode eggs and Giardia cyst. There was a consistently high level of attendance for the entire experimental period, with the exception of the first six days of the adaptation period. There were three preferential times for visiting the mineral feeder, approximately 07:00, 12:00 and 18:00 h. Individual daily mineral and FB intake was 229 +/- 27.21 g/day and 2 +/- 0.14 mg/kg BW/day, respectively, for the 14-day drug delivery period. The levels of fecal nematode eggs and Giardia cysts decreased significantly (<0.01) between pre- and post-sampling, with reductions of 92% for nematode eggs and 85% for Giardia cysts. Free choice medication for the control of gastrointestinal parasites is potentially effective, provided that the appropriate drug concentration, adaptation period, intake level and duration of treatment is utilized.
本研究旨在评估在自由选择矿物质补充剂中给育肥牛施用芬苯达唑（FB）的可行性。提供自由选择的FB可减少对动物的处理需求，并降低动物寄生虫感染水平。在7月和8月期间，使用体重400±19千克的荷斯坦育肥牛（n = 14和17）进行了两项独立试验。每头育肥牛都佩戴了一个独特的电子识别（EID）耳标，并随机分配到两组中的一组。这些耳标与配备了称重传感器的矿物质喂食器协同工作，每次动物进入电磁场时都会记录其EID编号。在两个为期8天的非药物矿物质（不含FB）期间确定个体每日矿物质摄入量和喂食时间，中间间隔一个为期14天的药物矿物质（0.55% FB）期间。在每个试验期开始和结束时收集粪便样本，并分析其中的胃肠道线虫卵和贾第虫囊肿。除适应期的前六天外，整个实验期的出勤率一直很高。有三个优先访问矿物质喂食器的时间，大约在07:00、12:00和18:00。在为期14天的给药期内，个体每日矿物质和FB摄入量分别为229±27.21克/天和2±0.14毫克/千克体重/天。采样前后粪便中线虫卵和贾第虫囊肿的水平显著下降（<0.01），线虫卵减少了92%，贾第虫囊肿减少了85%。只要使用适当的药物浓度、适应期、摄入量水平和治疗持续时间，自由选择药物控制胃肠道寄生虫可能是有效的。
