Kim S G, Stromberg M F, Kim M J, Volpicelli J R, Park J M
Department of Psychiatry, School of Medicine, Pusan National University, 1-ga 10, Ami-dong, Seo-gu, 602-739, Pusan, South Korea.
Alcohol. 2000 Oct;22(2):85-90. doi: 10.1016/s0741-8329(00)00109-9.
Several studies have demonstrated that non-selective opioid receptor antagonists effectively reduce alcohol consumption in both animal models and at the clinical level. However, research examining the contribution of specific opioid receptor subtypes to this effect has yielded conflicting results. Some of these studies have shown that the effect is contingent upon the action of mu receptors while others have suggested that delta receptors are primarily responsible. The data reported here re-examine this question using the alcohol-preferring C57BL/6 mice. The results of this experiment demonstrate that D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH(2) (CTOP), a mu-selective antagonist, and naltrindole, a delta-selective antagonist, are equally effective at reducing alcohol consumption in a limited access model compared to a saline control group. While there was no specific comparison of the effects of these drugs on alternative appetitive behavior, neither of these drugs had effects on measured off-session food or water consumption. The results of this experiment suggest that alcohol consumption is mediated by both mu- and delta-opioid receptor subtypes.
多项研究表明，非选择性阿片受体拮抗剂在动物模型和临床层面均能有效减少酒精摄入量。然而，关于特定阿片受体亚型对该效应的作用的研究结果却相互矛盾。其中一些研究表明，该效应取决于μ受体的作用，而另一些研究则表明δ受体起主要作用。本文报告的数据使用嗜酒的C57BL/6小鼠重新审视了这个问题。该实验结果表明，μ选择性拮抗剂D-苯丙氨酸-半胱氨酸-酪氨酸-D-色氨酸-鸟氨酸-苏氨酸-青霉胺-苏氨酸-NH₂（CTOP）和δ选择性拮抗剂纳曲吲哚，在有限接触模型中与生理盐水对照组相比，在减少酒精摄入量方面同样有效。虽然没有对这些药物对其他食欲行为的影响进行具体比较，但这两种药物对测量的非实验时段的食物或水摄入量均无影响。该实验结果表明，酒精摄入是由μ和δ阿片受体亚型共同介导的。
