Singh I P, Baron S
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Rev Med Virol. 2000 Nov-Dec;10(6):395-403. doi: 10.1002/1099-1654(200011/12)10:6<395::aid-rmv298>3.0.co;2-v.
Human blood plasma has been reported to possess nonspecific antiviral activity. This activity is due to several preexisting naturally occurring molecules that are either active against individual members or a family of viruses. These molecules, however, have not been adequately studied to reveal their molecular structures and mechanisms of action presumably because of their low and nonspecific antiviral action. Therefore, their possible role against viraemia remains unknown. Recently, two naturally occurring nonspecific broad-spectrum antiviral agents, University of Texas Inhibitor beta (UTIbeta) glycoprotein and high density lipoprotein, have been described in human serum. They are active against DNA and RNA viruses and one of them, UTIbeta, possesses significant antiviral activity of 40 units/mL. Since preexisting antiviral molecules in serum appear to be the only defence mechanisms available at the onset of viral infection they may have protective significance against viraemia. In view of this potential, we have undertaken to review the properties of these innate viral inhibitory molecules.
据报道，人血浆具有非特异性抗病毒活性。这种活性归因于几种预先存在的天然分子，这些分子要么对个别病毒成员有活性，要么对一类病毒有活性。然而，由于这些分子的抗病毒作用较弱且不具有特异性，尚未对其进行充分研究以揭示其分子结构和作用机制。因此，它们对病毒血症的可能作用仍然未知。最近，在人血清中发现了两种天然存在的非特异性广谱抗病毒剂，即德克萨斯大学抑制剂β（UTIβ）糖蛋白和高密度脂蛋白。它们对DNA和RNA病毒均有活性，其中一种UTIβ具有40单位/毫升的显著抗病毒活性。由于血清中预先存在的抗病毒分子似乎是病毒感染开始时唯一可用的防御机制，它们可能对病毒血症具有保护意义。鉴于这种潜力，我们已着手综述这些先天性病毒抑制分子的特性。
