与唑尼沙胺治疗相关的肾小管性酸中毒。
Renal tubular acidosis associated with zonisamide therapy.
作者信息
Inoue T, Kira R, Kaku Y, Ikeda K, Gondo K, Hara T
机构信息
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Epilepsia. 2000 Dec;41(12):1642-4. doi: 10.1111/j.1499-1654.2000.001642.x.
PURPOSE
We sought to report a previously undescribed adverse effect, renal tubular acidosis associated with zonisamide (ZNS) therapy.
METHODS
Ammonium chloride, bicarbonate, and furosemide loading tests were performed in an epileptic patient with metabolic acidosis and episodic hypokalemia who was treated with ZNS.
RESULTS
Distal renal tubular acidosis was diagnosed. On reexamination 7 weeks after ZNS had been replaced with phenytoin, the renal tubular acidosis disappeared.
CONCLUSIONS
This case indicates, for the first time, that ZNS might be a potential cause of renal tubular acidosis. Blood gases and serum electrolytes should be measured in patients undergoing ZNS therapy.
目的
我们试图报告一种先前未描述的不良反应，即与唑尼沙胺（ZNS）治疗相关的肾小管酸中毒。
方法
对一名接受ZNS治疗且患有代谢性酸中毒和发作性低钾血症的癫痫患者进行氯化铵、碳酸氢盐和速尿负荷试验。
结果
诊断为远端肾小管酸中毒。在用苯妥英钠替代ZNS 7周后复查时，肾小管酸中毒消失。
结论
该病例首次表明，ZNS可能是肾小管酸中毒的一个潜在原因。接受ZNS治疗的患者应检测血气和血清电解质。
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