Go Tohshin
Department of Infants' Brain and Cognitive Development, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
Childs Nerv Syst. 2009 Feb;25(2):237-40. doi: 10.1007/s00381-008-0687-4. Epub 2008 Aug 14.
The relationship between antiepileptic drugs (AEDs) polytherapy and urinary pH was studied to demonstrate the effect and difference of AED polytherapy compared to monotherapy.
A total of 271 urine samples from patients receiving AED polytherapy aged from 7 months to 35 years were enrolled. Two AEDs were co-administered to 215 patients, three AEDs to 45 patients, four AEDs to ten patients, and five AEDs to one patient.
The distribution of urinary pH shifted to the alkaline range with increasing numbers of co-administered AEDs (p < 0.0001). The distribution of urinary pH shifted to the alkaline side with AED polytherapy that included valproate (p < 0.05) or acetazolamide (p < 0.03). The distribution of urinary pH did not change with or without zonisamide, carbamazepine, phenobarbital, phenytoin, or clonazepam.
Urinary pH should be monitored in patients receiving AED polytherapy, particularly those receiving valproate, acetazolamide, or various AEDs in combination.
研究抗癫痫药物（AEDs）联合治疗与尿液pH值之间的关系，以证明AED联合治疗与单一治疗相比的效果及差异。
纳入271例接受AED联合治疗的患者的尿液样本，患者年龄从7个月至35岁。215例患者联合使用两种AED，45例患者联合使用三种AED，10例患者联合使用四种AED，1例患者联合使用五种AED。
随着联合使用AED数量的增加，尿液pH值分布向碱性范围偏移（p < 0.0001）。包含丙戊酸盐（p < 0.05）或乙酰唑胺（p < 0.03）的AED联合治疗使尿液pH值分布向碱性偏移。无论是否使用唑尼沙胺、卡马西平、苯巴比妥、苯妥英或氯硝西泮，尿液pH值分布均无变化。
接受AED联合治疗的患者，尤其是接受丙戊酸盐、乙酰唑胺或多种AED联合治疗的患者，应监测尿液pH值。
