Ochsenbein A F, Zinkernagel R M
Institute of Experimental Immunology, Switzerland.
Immunol Today. 2000 Dec;21(12):624-30. doi: 10.1016/s0167-5699(00)01754-0.
Natural or spontaneous antibodies are an essential part of the first line of defense against hematogenically spreading infections, including viruses. These antibodies target virus-antibody complexes and complement to the spleen. This prevents infections from reaching vital organs and enhances neutralizing antibody responses, particularly when the antibody is bound to a highly repetitive antigen.
天然或自发抗体是抵御包括病毒在内的血源性传播感染的第一道防线的重要组成部分。这些抗体靶向病毒 - 抗体复合物并将其补体导向脾脏。这可防止感染到达重要器官并增强中和抗体反应，特别是当抗体与高度重复的抗原结合时。
