Genetic imprinting: silencing elements have their say.
作者信息
Ferguson-Smith A C
机构信息
Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY,., Cambridge, UK.
出版信息
Curr Biol. 2000 Nov 30;10(23):R872-5. doi: 10.1016/s0960-9822(00)00817-4.
Abstract
Tissue-specific silencing elements have been identified that are required for imprinting of the individual genes in the Igf2-H19 domain of the mouse genome. These elements further elaborate the differences between the two parental chromosomes, and add a new feature to parent-of-origin-specific gene regulatory complexes.
摘要
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