Irby R B, Yeatman T J
Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, Florida, FL 33612, USA.
Oncogene. 2000 Nov 20;19(49):5636-42. doi: 10.1038/sj.onc.1203912.
Since the original identification of a transmissible agent responsible for the development of tumors in chickens, now known to be a retrovirus encoding the v-src gene, significant progress has been made in defining the potential functions of its human homolog, SRC. The product of the human SRC gene, c-Src, is found to be over-expressed and highly activated in a wide variety of human cancers. The relationship between Src activation and cancer progression appears to be significant. Moreover, Src may have an influence on the development of the metastatic phenotype. This review discusses the data supporting a role for c-Src as a critical component of the signal transduction pathways that control cancer cell development and growth, and provides the rationale for targeting Src in drug discovery efforts.
自从最初鉴定出一种可导致鸡发生肿瘤的传染性因子（现在已知是一种编码v-src基因的逆转录病毒）以来，在确定其人类同源物SRC的潜在功能方面已取得了重大进展。人类SRC基因的产物c-Src在多种人类癌症中被发现过度表达且高度激活。Src激活与癌症进展之间的关系似乎很显著。此外，Src可能对转移表型的发展有影响。本综述讨论了支持c-Src作为控制癌细胞发育和生长的信号转导通路关键组成部分的作用的数据，并为在药物研发中靶向Src提供了理论依据。
