眼科药物的致畸性。II. 硫柳汞的致畸性及组织蓄积。
Teratogenicities of ophthalmic drugs. II. Teratogenicities and tissue accumulation of thimerosal.
作者信息
Gasset A R, Itoi M, Ishii Y, Ramer R M
出版信息
Arch Ophthalmol. 1975 Jan;93(1):52-55. doi: 10.1001/archopht.1975.01010020056010.
Abstract
Under the conditions of this study, systemically or topically applied thimerosal was found to have no teratogenic effect even when given in concentrations approaching the 50% lethal dose of these compounds. A comparison of topical and subcutaneous administration of thimerosal to rabbits shows that a substantial concentration of mercury was present in blood and tissues of the treated animals and their offspring. Thimerosal was found to cross the blood-brain and placenta barriers.
摘要
在本研究条件下，发现全身或局部应用硫柳汞即使在接近这些化合物半数致死剂量的浓度下给药也没有致畸作用。对家兔局部和皮下给予硫柳汞的比较表明，在接受治疗的动物及其后代的血液和组织中存在大量汞浓度。发现硫柳汞可穿过血脑屏障和胎盘屏障。
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