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The thermoacidophilic archaeon Sulfolobus acidocaldarius contains an unusually short, highly reduced dolichyl phosphate.嗜热嗜酸古菌嗜酸热硫化叶菌含有一种异常短且高度还原的磷酸多萜醇。
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本文引用的文献

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Use of genomics to identify bacterial undecaprenyl pyrophosphate synthetase: cloning, expression, and characterization of the essential uppS gene.利用基因组学鉴定细菌十一异戊二烯焦磷酸合成酶：必需基因uppS的克隆、表达及特性分析
J Bacteriol. 1999 Jan;181(2):483-92. doi: 10.1128/JB.181.2.483-492.1999.
2
The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.酵母RER2基因是通过内质网蛋白定位突变鉴定出来的，它编码顺式异戊二烯基转移酶，这是一种在多萜醇合成中的关键酶。
Mol Cell Biol. 1999 Jan;19(1):471-83. doi: 10.1128/MCB.19.1.471.
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Molecular cloning, expression, and purification of undecaprenyl diphosphate synthase. No sequence similarity between E- and Z-prenyl diphosphate synthases.十一异戊二烯基二磷酸合酶的分子克隆、表达及纯化。E型和Z型异戊二烯基二磷酸合酶之间无序列相似性。
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Purification and characterization of farnesyl diphosphate/geranylgeranyl diphosphate synthase. A thermostable bifunctional enzyme from Methanobacterium thermoautotrophicum.法尼基二磷酸/香叶基香叶基二磷酸合酶的纯化与特性鉴定。来自嗜热自养甲烷杆菌的一种热稳定双功能酶。
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5
Archaebacterial ether-linked lipid biosynthetic gene. Expression cloning, sequencing, and characterization of geranylgeranyl-diphosphate synthase.古细菌醚连接脂质生物合成基因。牻牛儿基牻牛儿基二磷酸合酶的表达克隆、测序及特性分析。
J Biol Chem. 1994 May 20;269(20):14792-7.
6
Inhibition of glycosylation by amphomycin and sugar nucleotide analogs PP36 and PP55 indicates that Haloferax volcanii beta-glucosylates both glycoproteins and glycolipids through lipid-linked sugar intermediates: evidence for three novel glycoproteins and a novel sulfated dihexosyl-archaeol glycolipid.两性霉素以及糖核苷酸类似物PP36和PP55对糖基化的抑制作用表明，嗜盐栖热袍菌通过脂质连接的糖中间体对糖蛋白和糖脂进行β-葡萄糖基化：发现三种新型糖蛋白和一种新型硫酸化二己糖古菌醇糖脂的证据。
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Efficient enzymatic hydrolysis of polyprenyl pyrophosphates.
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Phospholipase A2 activity towards phosphatidylcholine in mixed micelles: surface dilution kinetics and the effect of thermotropic phase transitions.磷脂酶A2对混合胶束中磷脂酰胆碱的活性：表面稀释动力学及热致相变的影响
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Kinetic dependence of phospholipase A 2 activity on the detergent Triton X-100.磷脂酶A 2活性对去污剂Triton X - 100的动力学依赖性。
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Biosynthesis of sulfated saccharides N-glycosidically linked to the protein via glucose. Purification and identification of sulfated dolichyl monophosphoryl tetrasaccharides from halobacteria.通过葡萄糖与蛋白质N-糖苷键连接的硫酸化糖类的生物合成。从嗜盐菌中纯化和鉴定硫酸化二磷酸多萜醇四糖。
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嗜热嗜酸古菌嗜酸热硫化叶菌顺式聚异戊二烯二磷酸合酶的克隆、表达及特性分析

Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius.

作者信息

Hemmi H, Yamashita S, Shimoyama T, Nakayama T, Nishino T

机构信息

Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Aoba-yama 07, Sendai, Miyagi 980-8579, Japan.

出版信息

J Bacteriol. 2001 Jan;183(1):401-4. doi: 10.1128/JB.183.1.401-404.2001.

DOI:10.1128/JB.183.1.401-404.2001
PMID:11114943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC94892/
Abstract

cis-polyprenyl diphosphate synthases are involved in the biosynthesis of the glycosyl carrier lipid in most organisms. However, only little is known about this enzyme of archaea. In this report, we isolated the gene of cis-polyprenyl diphosphate synthase from a thermoacidophilic archaeon, Sulfolobus acidocaldarius, and characterized the recombinant enzyme.

摘要

顺式聚异戊二烯二磷酸合酶参与大多数生物体中糖基载体脂质的生物合成。然而，关于古细菌的这种酶，人们了解甚少。在本报告中，我们从嗜热嗜酸古细菌嗜酸热硫化叶菌中分离出顺式聚异戊二烯二磷酸合酶基因，并对重组酶进行了表征。