van Oostrom A J, Castro Cabezas M, Ribalta J, Masana L, Twickler T B, Remijnse T A, Erkelens D W
University Hospital Utrecht, Utrecht, The Netherlands, University Rovira I Virgili, Reus, Spain.
Eur J Clin Invest. 2000 Nov;30(11):964-71. doi: 10.1046/j.1365-2362.2000.00732.x.
Elevated fasting and postprandial triglycerides (TG) are established risk factors for Coronary Heart Disease (CHD). Usually, fasting plasma TG are measured, although TG are mainly produced in a postprandial state. Our objective was to investigate diurnal TG profiles using serial capillary TG measurements, in normolipidemic healthy males.
Forty-eight, non-obese, non-smoking males (range: 20-55 years, mean age: 32 +/- 12 years), measured diurnal capillary TG, at six fixed timepoints during the day on three different days and recorded their food intake. Insulin sensitivity was estimated by HOMA. Diurnal capillary TG profiles were calculated as integrated area under the mean capillary TG curve (TGc-AUC).
All subjects had normal fasting plasma TG and cholesterol. The average TGc-AUC was 23.6 +/- 6.7 mmol h L-1. Significant correlations with TGc-AUC were: fasting insulin (r = 0. 40, P < 0.005), HOMA (r = 0.32, P < 0.05), relative fat mass (r = 0. 31, P < 0.05), dietary protein-(r = 0.31, P < 0.05) and saturated fat intake (r = 0.30, P < 0.05). Age was not associated to diurnal triglyceridemia. After subdividing the group into quartiles on the base of TGc-AUC, differences were found between the highest (n = 12) and lowest quartile (n = 12) for: fasting capillary TG, fasting insulin, HOMA and systolic blood pressure. Fasting plasma TG and dietary intake were not different.
Diurnal TG profiles in healthy normolipidemic males are not age-dependent, but are associated to insulin sensitivity, fat mass and diet. Diurnal capillary TG profiles may be a valuable additional tool in estimating a risk profile for CHD since significant differences in diurnal TG are not always reflected by elevated fasting plasma TG.
空腹和餐后甘油三酯（TG）升高是冠心病（CHD）公认的危险因素。通常测量空腹血浆TG，尽管TG主要在餐后状态下产生。我们的目的是通过连续毛细血管TG测量来研究血脂正常的健康男性的昼夜TG谱。
48名非肥胖、不吸烟男性（年龄范围：20 - 55岁，平均年龄：32±12岁），在三天内的六个固定时间点测量昼夜毛细血管TG，并记录他们的食物摄入量。通过稳态模型评估（HOMA）来估计胰岛素敏感性。昼夜毛细血管TG谱通过平均毛细血管TG曲线下的积分面积（TGc - AUC）计算得出。
所有受试者空腹血浆TG和胆固醇均正常。平均TGc - AUC为23.6±6.7 mmol·h·L⁻¹。与TGc - AUC显著相关的因素有：空腹胰岛素（r = 0.40，P < 0.005）、HOMA（r = 0.32，P < 0.05）、相对脂肪量（r = 0.31，P < 0.05）、膳食蛋白质摄入量（r = 0.31，P < 0.05）和饱和脂肪摄入量（r = 0.30，P < 0.05）。年龄与昼夜甘油三酯血症无关。根据TGc - AUC将该组分为四分位数后，发现最高四分位数组（n = 12）和最低四分位数组（n = 12）在空腹毛细血管TG、空腹胰岛素、HOMA和收缩压方面存在差异。空腹血浆TG和饮食摄入量无差异。
健康血脂正常男性的昼夜TG谱与年龄无关，但与胰岛素敏感性、脂肪量和饮食有关。昼夜毛细血管TG谱可能是评估冠心病风险谱的一个有价值的附加工具，因为昼夜TG的显著差异并不总是通过空腹血浆TG升高来反映。
