15种人胰腺癌细胞系中K-ras、p53、p16和SMAD4基因的突变特征分析。

Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.

作者信息

Sun C, Yamato T, Furukawa T, Ohnishi Y, Kijima H, Horii A

机构信息

Department of Molecular Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8575, Japan.

出版信息

Oncol Rep. 2001 Jan-Feb;8(1):89-92. doi: 10.3892/or.8.1.89.

DOI:10.3892/or.8.1.89

PMID:11115575

Abstract

Human pancreatic cancer is one of the most malignant diseases in the world. In order to save patients with pancreatic cancer, it is necessary to develop novel methods for treatment. For such a purpose, a series of well-characterized cancer cell lines are of great help for in vitro studies that are generally the first step in approaching the invention of novel methods for treatment. In the present study, we analyzed 15 human pancreatic cancer cell lines for genetic alterations of the K-ras, p53, p16, and SMAD4 genes, which are very frequent targets for mutation in pancreatic cancer; these cell lines are useful resources in cancer research.

摘要

人类胰腺癌是世界上最恶性的疾病之一。为了挽救胰腺癌患者，有必要开发新的治疗方法。出于这个目的，一系列特征明确的癌细胞系对体外研究有很大帮助，而体外研究通常是开发新治疗方法的第一步。在本研究中，我们分析了15种人类胰腺癌细胞系中K-ras、p53、p16和SMAD4基因的基因改变情况，这些基因是胰腺癌中非常常见的突变靶点；这些细胞系是癌症研究中的有用资源。