胸苷磷酸化酶在结直肠癌中的表达意义。
The significance of thymidine phosphorylase expression in colorectal cancer.
作者信息
Katsumata K, Sumi T, Yamashita S, Takahashi S, Mori M, Baba T, Murohashi T, Nagashima K, Ashizawa T, Yamamoto K, Koyanagi Y, Katoh K
机构信息
Department of Gastroenterology, Hatiouji Medical Center, Tokyo Medical University, Hatiouji-shi, Tokyo 193-0998, Japan.
出版信息
Oncol Rep. 2001 Jan-Feb;8(1):127-30. doi: 10.3892/or.8.1.127.
We measured thymidine phosphorylase activity in colorectal cancer tissue and conducted immunostaining to investigate enzyme expression in the tumor tissue. The results showed a correlation between staining ratio of thymidine phosphorylase and cancer progression as well as a correlation between enzyme activity and staining ratios of cancer cells and stromal cells. Since enzyme activity levels can be judged by staining ratios, this method may be useful for assessing cancer malignancy.
我们测量了结直肠癌组织中的胸苷磷酸化酶活性，并进行免疫染色以研究肿瘤组织中的酶表达。结果显示胸苷磷酸化酶的染色率与癌症进展之间存在相关性，以及酶活性与癌细胞和基质细胞的染色率之间存在相关性。由于酶活性水平可通过染色率来判断，该方法可能有助于评估癌症的恶性程度。
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