Magazanik L G, Potap'eva N N
Biull Eksp Biol Med. 1975 Jan;79(1):39-41.
The blocking action of alpha-polypeptides from the venoms of elapid snakes (Bungarus multicinctus and Naja naja siamensis) was studied on leech dorsal muscle. It was shown that these neurotoxins failed to inhibit the responses to mononitrogen cholinomimetics (acetylcholine, nicotine, carbamylcholine, etc.). The capacity of neurotoxins to inhibit the responses to the bisquaternary cholinommimetics depended upon the length of the molecule. The neurotoxins were active against the "shorter" cholinomimetics, such as decamethonium, and bischolinic esters of malonic, succinic and glutaric acids. The "longer" cholinomimetics (bischolinic esters of adipinic, pimelic, suberic, azelaic, sebacic acids retained their full activity after the treatment of leech dorsal muscle by neurotoxins. Possible explanations of the selective action of neurotoxins are discussed.
研究了眼镜蛇科蛇（银环蛇和眼镜蛇）毒液中的α-多肽对水蛭背肌的阻断作用。结果表明，这些神经毒素不能抑制对单氮类拟胆碱药（乙酰胆碱、尼古丁、氨甲酰胆碱等）的反应。神经毒素抑制对双季铵类拟胆碱药反应的能力取决于分子的长度。神经毒素对“较短”的拟胆碱药如十烃季铵以及丙二酸、琥珀酸和戊二酸的双胆碱酯有活性。“较长”的拟胆碱药（己二酸、庚二酸、辛二酸、壬二酸、癸二酸的双胆碱酯）在经神经毒素处理水蛭背肌后仍保持其全部活性。文中讨论了神经毒素选择性作用的可能解释。
